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Article

The role of neuroinflammation and amyloid in cognitive impairment in an APP/PS1 transgenic mouse model of Alzheimer's disease.

CNS neuroscience & therapeutics - 1 Apr 2017

Zhu Shenghua, Wang Junhui, Zhang Yanbo, He Jue, Kong Jiming, Wang Jun-Feng, Li Xin-Min

Abstract excerpt

AIMS: Both amyloid deposition and neuroinflammation appear in the early course of Alzheimer's disease (AD). However, the progression of neuroinflammation and its relationship with amyloid deposition and behavioral changes have not been fully elucidated. A better understanding the role of neuroinflammation in AD might extend our current knowledge to therapeutic intervention possibilities. METHODS: This study...

Topics

Age Factors
Alzheimer Disease
Amyloid beta-Peptides
Amyloid beta-Protein Precursor
Animals
Brain
CD11b Antigen
Cognition Disorders
Disease Models, Animal
Glial Fibrillary Acidic Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Maze Learning

Mice

Mice, Inbred C57BL

Mice, Transgenic

Microglia

Mutation

Neurons

Source

Open in PubMed Open full text

Identifiers

PMID: 28191738
DOI: 10.1111/cns.12677
PMCID: PMC6492725

Genes

APP
GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-28191738-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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