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Article

Repair-independent functions of DNA-PKcs protect irradiated cells from mitotic slippage and accelerated senescence

12 Jun 2019

Abstract excerpt

The binding of DNA-dependent protein kinase catalytic subunit (DNA-PKcs, also known as PRKDC) to Ku proteins at DNA double-strand breaks (DSBs) has long been considered essential for non-homologous end joining (NHEJ) repair, providing a rationale for use of DNA-PKcs inhibitors as cancer therapeutics. Given lagging clinical translation, we reexamined mechanisms and observed instead that DSB repair can proceed...

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PMID: 31189537
DOI: 10.1242/jcs.229385

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