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DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis

15 Dec 2016

Abstract excerpt

The DNA damage response (DDR) orchestrates a network of cellular processes that integrates cell-cycle control and DNA repair or apoptosis, which serves to maintain genome stability. DNA-PKcs (the catalytic subunit of the DNA-dependent kinase, encoded by PRKDC ), ATM (ataxia telangiectasia, mutated), and ATR (ATM and Rad3-related) are related PI3K-like protein kinases and central regulators of the DDR. Defects in...

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PMID: 28123024
DOI: 10.1523/jneurosci.4213-15.2016

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