Genome-wide mapping and profiling of γH2AX binding hotspots in response to different replication stress inducers

Abstract excerpt

BACKGROUND: Replication stress (RS) gives rise to DNA damage that threatens genome stability. RS can originate from different sources that stall replication by diverse mechanisms. However, the mechanism underlying how different types of RS contribute to genome instability is unclear, in part due to the poor understanding of the distribution and characteristics of damage sites induced by different RS mechanisms....

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