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Article

Replication stress induces micronuclei comprising of aggregated DNA double-strand breaks.

PloS one - 15 Apr 2011

Xu Bing, Sun Zhaoliang, Liu Zhaojian, Guo Haiyang, Liu Qiao, Jiang Haiyan, Zou Yongxin, Gong Yaoqin, Tischfield Jay A, Shao Changshun

Abstract excerpt

BACKGROUND: Micronuclei (MN) in mammalian cells serve as a reliable biomarker of genomic instability and genotoxic exposure. Elevation of MN is commonly observed in cells bearing intrinsic genomic instability and in normal cells exposed to genotoxic agents. DNA double-strand breaks are marked by phosphorylation of H2AX at serine 139 (γ-H2AX). One subclass of MN contains massive and uniform γ-H2AX signals. This...

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Identifiers

PMID: 21525980
DOI: 10.1371/journal.pone.0018618
PMCID: PMC3078113

Genes

RPA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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