Article

Chromosomal rearrangements at hypomethylated Satellite 2 sequences are associated with impaired replication efficiency and increased fork stalling

2019-02-19

Abstract excerpt

Cancer cells, aging cells, and cells from patients with the developmental disorder Immunodeficiency, C entromeric instability, and F acial anomalies (ICF) syndrome frequently display a striking loss of DNA methylation (hypomethylation) that is accompanied by increased DNA damage and chromosomal rearrangements. Despite the robust link, the mechanism by which hypomethylation leads to genomic instability is poorly...

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Literature Corpus work: 56a46d83-92e6-5319-add2-469029985ebf
DOI: 10.1101/554410

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