Article
CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP.
Molecular cancer research : MCR - 1 Oct 2019
Moure Casey J, Diplas Bill H, Chen Lee H, Yang Rui, Pirozzi Christopher J, Wang Zhaohui, Spasojevic Ivan, Waitkus Matthew S, He Yiping, Yan Hai
Abstract excerpt
Mutations in isocitrate dehydrogenases 1 and 2 (IDH) occur in the majority of World Health Organization grade II and III gliomas. IDH1/2 active site mutations confer a neomorphic enzyme activity producing the oncometabolite D-2-hydroxyglutarate (D-2HG), which generates the glioma CpG island methylation phenotype (G-CIMP). While IDH1/2 mutations and G-CIMP are commonly retained during tumor recurrence, recent work...
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