Article
A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation.
Genome research - 1 Dec 2012
Duncan Christopher G, Barwick Benjamin G, Jin Genglin, Rago Carlo, Kapoor-Vazirani Priya, Powell Doris R, Chi Jen-Tsan, Bigner Darell D, Vertino Paula M, Yan Hai
Abstract excerpt
Monoallelic point mutations of the NADP(+)-dependent isocitrate dehydrogenases IDH1 and IDH2 occur frequently in gliomas, acute myeloid leukemias, and chondromas, and display robust association with specific DNA hypermethylation signatures. Here we show that heterozygous expression of the IDH1(R132H) allele is sufficient to induce the genome-wide alterations in DNA methylation characteristic of these tumors....
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