Article
Epigenetic suppression of EGFR signaling in G-CIMP+ glioblastomas.
Oncotarget - 15 Sept 2014
Li Jie, Taich Zachary J, Goyal Amit, Gonda David, Akers Johnny, Adhikari Bandita, Patel Kunal, Vandenberg Scott, Yan Wei, Bao Zhaoshi, Carter Bob S, Wang Renzhi, Mao Ying, Jiang Tao, Chen Clark C
Abstract excerpt
The intrinsic signaling cascades and cell states associated with the Glioma CpG Island Methylator Phenotype (G-CIMP) remain poorly understood. Using published mRNA signatures associated with EGFR activation, we demonstrate that G-CIMP+ tumors harbor decreased EGFR signaling using three independent datasets, including the Chinese Glioma Genome Atlas(CGGA; n=155), the REMBRANDT dataset (n=288), and The Cancer...
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