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Article

Stability of the CpG island methylator phenotype during glioma progression and identification of methylated loci in secondary glioblastomas.

BMC cancer - 10 Jul 2014

Hill Victoria K, Shinawi Thoraia, Ricketts Christopher J, Krex Dietmar, Schackert Gabriele, Bauer Julien, Wei Wenbin, Cruickshank Garth, Maher Eamonn R, Latif Farida

Abstract excerpt

BACKGROUND: Grade IV glioblastomas exist in two forms, primary (de novo) glioblastomas (pGBM) that arise without precursor lesions, and the less common secondary glioblastomas (sGBM) which develop from earlier lower grade lesions. Genetic heterogeneity between pGBM and sGBM has been documented as have differences in the methylation of individual genes. A hypermethylator phenotype in grade IV GBMs is now well...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25012071
DOI: 10.1186/1471-2407-14-506
PMCID: PMC4227105

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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