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Article

Tumor-suppressive miR148a is silenced by CpG island hypermethylation in IDH1-mutant gliomas.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2014

Li Sichen, Chowdhury Reshmi, Liu Fei, Chou Arthur P, Li Tie, Mody Reema R, Lou Jerry J, Chen Weidong, Reiss Jean, Soto Horacio, Prins Robert, Liau Linda M, Mischel Paul S, Nghiemphu Phioanh L, Yong William H, Cloughesy Timothy F, Lai Albert

Abstract excerpt

PURPOSE: IDH1/2-mutant gliomas harbor a distinct glioma-CpG island methylation phenotype (G-CIMP) that may promote the initiation and progression of secondary pathway gliomas by silencing tumor-suppressive genes. The potential role of tumor-suppressive microRNAs (miRNA; miR) in this process is not understood. EXPERIMENTAL DESIGN: To identify potential tumor-suppressive miRNA hypermethylated in glioma, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25224277
DOI: 10.1158/1078-0432.CCR-14-0234
PMCID: PMC4233178

Genes

IDH1
DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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