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Article

Cardioprotection by the mitochondrial unfolded protein response requires ATF5

5 Jul 2019

Abstract excerpt

The mitochondrial unfolded protein response (UPR mt ) is a cytoprotective signaling pathway triggered by mitochondrial dysfunction. UPR mt activation upregulates chaperones, proteases, antioxidants, and glycolysis at the gene level to restore proteostasis and cell energetics. Activating transcription factor 5 (ATF5) is a proposed mediator of the mammalian UPR mt . Herein, we hypothesized pharmacological UPR mt...

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PMID: 31274354
DOI: 10.1152/ajpheart.00244.2019

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