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ATM-associated signalling triggers the unfolded protein response and cell death in response to stress

14 Jul 2020

Abstract excerpt

Endoplasmic reticulum (ER) stress can be caused by perturbations in ER function resulting from the accumulation of unfolded/misfolded proteins in the ER lumen. Accumulating unfolded proteins trigger unfolded protein responses (UPRs) through activating three transmembrane sensors on the ER: IRE1α, PERK, and ATF6. The orchestrated action of these molecules upregulates genes encoding proteins involved in the...

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PMID: 32665601
DOI: 10.1038/s42003-020-1102-2

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