Article

Age-related decline of the unfolded protein response in the heart promotes protein misfolding and cardiac pathology

2021-06-16

Abstract excerpt

Cardiac myocyte death during heart failure is particularly detrimental, given that cardiac muscle exhibits limited regenerative potential. Protein aggregation was previously observed in end-stage heart failure, suggesting protein-misfolding in cardiac myocytes as a contributor to the disease process. However, the relationship between protein-misfolding, cardiac myocyte death, and myocardial dysfunction is yet to b...

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Literature Corpus work: 48c65d7e-f15d-5f0f-9ca8-2ec33342b743
DOI: 10.1101/2021.06.16.448596

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