Article

ATF5-Dependent GDF15 Expression Mediates Anesthesia-Induced Neuroprotection Against Stroke

2024-12-11

Abstract excerpt

The incidence of perioperative stroke, a rare but severe complication, is increasing in aging populations. Although anesthetics such as sevoflurane may provide protective preconditioning against ischemic injury, clinical outcomes have been inconsistent. In this study, we demonstrated that sevoflurane-induced neuroprotection is associated with the upregulation of genes involved in the mitochondrial unfolded protein...

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Literature Corpus work: cc30bea2-cf23-5587-b252-8802a9ab42f5
DOI: 10.1101/2024.12.06.627155

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