Article

The Mitochondrial Unfolded Protein Response (UPRmt), Regulated by ATF5, Attenuates Doxorubicin Induced Cardiotoxicity.

2026-03-17

Abstract excerpt

<h4>Background: </h4> and Purpose: The mitochondrial unfolded protein response (UPR mt ), is a highly conserved, evolutionary stress response, which maintains mitochondrial homeostasis. UPR mt signaling has been shown to be cytoprotective in various cardiovascular pathologies. However, whether the UPR mt attenuates doxorubicin (DOX) induced cardiotoxicity, is unknown. This study sought to determine whether DOX...

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Literature Corpus work: 1cff4d62-98f1-58c1-8e2e-d6c25c019cd0
DOI: 10.22541/au.177374781.12525533/v1

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