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Unfolded proteins in the mitochondria activate HRI and shut-down of mitochondrial protein translation

2024-03-21

Abstract excerpt

Mitochondrial unfolded protein response (UPR mt ) is triggered through eIF2α phosphorylation in mammal. However, the mechanisms of UPR mt activation and the influence on mitochondrial protein translation through eIF2α phosphorylation remain unclear. In this study, we confirmed that UPR mt was a rapid and specific stress response through eIF2α phosphorylation with pharmacological induction, along with the protein e...

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Identifiers and source

Literature Corpus work
97b648fe-6ff3-57d3-acd7-231cb1fd2b0c
DOI
10.21203/rs.3.rs-4121132/v1
Open publication

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