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Article

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals.

The Journal of cell biology - 3 Jul 2017

Quirós Pedro M, Prado Miguel A, Zamboni Nicola, D'Amico Davide, Williams Robert W, Finley Daniel, Gygi Steven P, Auwerx Johan

Abstract excerpt

Mitochondrial stress activates a mitonuclear response to safeguard and repair mitochondrial function and to adapt cellular metabolism to stress. Using a multiomics approach in mammalian cells treated with four types of mitochondrial stressors, we identify activating transcription factor 4 (ATF4) as the main regulator of the stress response. Surprisingly, canonical mitochondrial unfolded protein response genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28566324
DOI: 10.1083/jcb.201702058
PMCID: PMC5496626

Genes

ATF4
ATF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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