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Aging triggers mitochondrial, endoplasmic reticulum, and metabolic stress responses in the heart

18 Feb 2025

Abstract excerpt

Introduction: Aging is a multifaceted biological process characterized by a progressive decline in cellular and tissue function. It significantly impacts the cardiovascular system and contributes to the onset of cardiovascular diseases. The mitochondria (mt) and the endoplasmic reticulum (ER) play synergistic roles in maintaining cellular homeostasis and energy production in the heart. Nevertheless, their...

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PMID: 40124955
DOI: 10.20517/jca.2024.17

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