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The mitochondrial integrated stress response: A novel approach to anti-aging and pro-longevity

26 Nov 2024

Abstract excerpt

The ISR is a cellular signaling pathway that responds to various physiological changes and types of stimulation. The mitochondrial integrated stress response (ISR mt ) is a stress response specific to mitochondria which is initiated by eIF2α phosphorylation and is responsive to mitochondrial stressors. The ISR mt triggers diverse metabolic responses reliant on activating transcription factor 4 (ATF4). The...

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PMID: 39608727
DOI: 10.1016/j.arr.2024.102603

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