Article
The biological features of PanIN initiated from oncogenic Kras mutation in genetically engineered mouse models.
Cancer letters - 1 Oct 2013
Shen Ruizhe, Wang Qi, Cheng Shidan, Liu Tingting, Jiang He, Zhu Jiaxing, Wu Yunlin, Wang Lifu
Abstract excerpt
Pancreatic intraepithelial neoplasia (PanIN) is the most common premalignant lesion of the pancreas. Further understanding of the biological behavior and molecular genetic alterations in the stepwise progression of PanINs is necessary toward the development of pancreatic ductal adenocarcinoma (PDAC) interventions. In this study, we analyzed the morphological characteristics, molecular alterations, and biological...
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