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Article

Kras-driven heterotopic tumor development from hepatobiliary organoids

1 Feb 2019

Abstract excerpt

Cancers arising from the biliary tract are refractory to conventional therapies, requiring the development of novel therapeutics. However, only a limited number of genetically engineered mouse models have been created, partly because of time-consuming work required. Besides, liver-specific gene manipulation mostly resulted in concurrent development of hepatocellular carcinoma, another type of liver cancer, and...

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Share to Cholangiocarcinoma and Gallbladder Cancer Studies
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PMID: 30753336
DOI: 10.1093/carcin/bgz024

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