Article

Organotypic Culture of Acinar Cells for the Study of Pancreatic Cancer Initiation

2020-08-08

Abstract excerpt

Multi-step evolution characterizes the carcinogenesis of GI malignancies, where the disease progresses through the accrual of genetic mutations, co-option of multiple host cellular factors and the acquisition of increasingly aggressive pathological features. Ensuing cancer complexity and plasticity are challenges for therapeutic approaches. On the other hand, disease inception is often triggered by a defined oncog...

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Literature Corpus work: 96719953-d1c9-59c0-bd35-fbaf8b3ea0b2
DOI: 10.20944/preprints202008.0216.v1

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