Article
Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells.
Nature communications - 8 Mar 2017
Lee Jonghyeob, Snyder Emily R, Liu Yinghua, Gu Xueying, Wang Jing, Flowers Brittany M, Kim Yoo Jung, Park Sangbin, Szot Gregory L, Hruban Ralph H, Longacre Teri A, Kim Seung K
Abstract excerpt
Development of systems that reconstitute hallmark features of human pancreatic intraepithelial neoplasia (PanINs), the precursor to pancreatic ductal adenocarcinoma, could generate new strategies for early diagnosis and intervention. However, human cell-based PanIN models with defined mutations are unavailable. Here, we report that genetic modification of primary human pancreatic cells leads to development of...
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