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Pathogenesis of Pancreatic Cancer

31 Oct 2013

Abstract excerpt

The past several decades have seen great effort devoted to mimicking the key features of pancreatic ductal adenocarcinoma (PDAC) in animals and have produced 2 robust models of this deadly cancer. Carcinogen-treated Syrian hamsters develop PDAC with genetic lesions, which reproduce those of human, including activation of the Kras oncogene, and early studies in this species validated nongenetic risk factors for...

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PMID: 24178582
DOI: 10.1177/0192623313508250

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