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Article

Modeling pancreatic cancer in mice for experimental therapeutics.

Biochimica et biophysica acta. Reviews on cancer - 1 Aug 2021

Mallya Kavita, Gautam Shailendra K, Aithal Abhijit, Batra Surinder K, Jain Maneesh

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy that is characterized by early metastasis, low resectability, high recurrence, and therapy resistance. The experimental mouse models have played a central role in understanding the pathobiology of PDAC and in the preclinical evaluation of various therapeutic modalities. Different mouse models with targetable pathological hallmarks have been...

Topics

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Antineoplastic Agents
Carcinoma, Pancreatic Ductal
Drug Resistance, Neoplasm
Immunotherapy
Neoplasms, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pancreatic Neoplasms

Tumor Microenvironment

Xenograft Model Antitumor Assays

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Identifiers

PMID: 33945847
DOI: 10.1016/j.bbcan.2021.188554
PMCID: PMC8570383

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