Article
Methylation profiling identifies 2 groups of gliomas according to their tumorigenesis.
Neuro-oncology - 1 Jan 2011
Laffaire Julien, Everhard Sibille, Idbaih Ahmed, Crinière Emmanuelle, Marie Yannick, de Reyniès Aurelien, Schiappa Renaud, Mokhtari Karima, Hoang-Xuan Khê, Sanson Marc, Delattre Jean-Yves, Thillet Joëlle, Ducray François
Abstract excerpt
Extensive genomic and gene expression studies have been performed in gliomas, but the epigenetic alterations that characterize different subtypes of gliomas remain largely unknown. Here, we analyzed the methylation patterns of 807 genes (1536 CpGs) in a series of 33 low-grade gliomas (LGGs), 36 g...
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