Article
Genetic risk for alzheimer disease is distinct from genetic risk for amyloid deposition.
Annals of neurology - 1 Sept 2019
Leonenko Ganna, Shoai Maryam, Bellou Eftychia, Sims Rebecca, Williams Julie, Hardy John, Escott-Price Valentina
Abstract excerpt
OBJECTIVE: Alzheimer disease (AD) is the most common form of dementia and is responsible for a huge and growing health care burden in the developed and developing world. The polygenic risk score (PRS) approach has shown 75 to 84% prediction accuracy of identifying individuals with AD risk. METHODS: In this study, we tested the prediction accuracy of AD, mild cognitive impairment (MCI), and amyloid deposition...
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