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Article

Association of Polygenic Risk Score for 5 Diseases With Alzheimer Disease Progression, Biomarkers, and Amyloid Deposition.

Neurology - 25 Feb 2025

Liang Jingjing, Hussainy Sadiya, Lee Sara Michelle, Wu Gray, Bautista Natalie, Ding Mao, Wang Heming, LaFleur Bonnie, Perry George, Wang Xinglong

Abstract excerpt

BACKGROUND AND OBJECTIVES: Alzheimer disease (AD) is a heterogeneous neurodegenerative disorder influenced by genetic and environmental factors. Conditions such as type 2 diabetes (T2D), cardiovascular disease, obesity, depression, and obstructive sleep apnea (OSA) increase AD risk and progression. This study aimed to examine the genetic predisposition to these conditions and their effect on AD pathophysiology,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39836940
DOI: 10.1212/WNL.0000000000210250
PMCID: PMC11748256

Genes

CAD

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