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Article

NPM1c alters FLT3-D835Y localization and signaling in acute myeloid leukemia

11 Jun 2019

Abstract excerpt

Activating mutations in FMS-like tyrosine kinase receptor-3 (FLT3) and Nucleophosmin-1 (NPM1) are most frequent alterations in acute myeloid leukemia (AML), and are often coincidental. The mutational status of NPM1 has strong prognostic relevance to patients with point mutations of the FLT3 tyrosine kinase domain (TKD), but the biological mechanism underlying this effect remains unclear. In the present study, we...

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PMID: 31186273
DOI: 10.1182/blood.2018883140

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