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Identification of a novel NPM1 mutation in acute myeloid leukemia

4 Oct 2023

Abstract excerpt

Nucleophosmin (NPM1) is a widely expressed nucleocytoplasmic shuttling protein with prominent nucleolar localization. It is estimated that 25-35% of adult patients with acute myeloid leukemia (AML) carry NPM1 mutations. The classic NPM1 type A mutation occurs in exon 12, which accounts for 75-80% of adult patients with NPM1-mutated AML. It produces an additional leucine and valine-rich nuclear export signal (NES)...

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PMID: 37794441
DOI: 10.1186/s40164-023-00449-4

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