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GATA1 epigenetic deregulation contributes to the development of AML with NPM1 and FLT3-ITD cooperating mutations

12 Feb 2019

Abstract excerpt

About 20 recurrently mutated genes are known to be involved in the molecular pathogenesis of acute myeloid leukemia (AML) [ 1 ]. Among them, Nucleophosmin ( NPM1 ) and FLT3 -ITD mutations frequently occur together in adults with AML [ 2 ], suggesting cooperative leukemogenesis. To date, the molecular consequences of these cooperative genetic alterations in AML are still elusive. To address this issue, we crossed...

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PMID: 30755706
DOI: 10.1038/s41375-019-0399-7

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