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Article

Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice.

Nature genetics - 1 May 2011

Vassiliou George S, Cooper Jonathan L, Rad Roland, Li Juan, Rice Stephen, Uren Anthony, Rad Lena, Ellis Peter, Andrews Rob, Banerjee Ruby, Grove Carolyn, Wang Wei, Liu Pentao, Wright Penny, Arends Mark, Bradley Allan

Abstract excerpt

Acute myeloid leukemia (AML) is a molecularly diverse malignancy with a poor prognosis whose largest subgroup is characterized by somatic mutations in NPM1, which encodes nucleophosmin. These mutations, termed NPM1c, result in cytoplasmic dislocation of nucleophosmin and are associated with distinctive transcriptional signatures, yet their role in leukemogenesis remains obscure. Here we report that activation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21441929
DOI: 10.1038/ng.796
PMCID: PMC3084174

Genes

NPM1

Provenance

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