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Article

NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease.

Experimental hematology - 1 Feb 2014

Rau Rachel, Magoon Daniel, Greenblatt Sarah, Li Li, Annesley Colleen, Duffield Amy S, Huso David, McIntyre Emily, Clohessy John G, Reschke Markus, Pandolfi Pier Paolo, Small Donald, Brown Patrick

Abstract excerpt

Cytoplasmic nucleophosmin (NPMc(+)) mutations and FMS-like tyrosine kinase 3 (FLT3) internal tandem duplication (ITD) mutations are two of the most common known molecular alterations in acute myeloid leukemia (AML); they frequently occur together, suggesting cooperative leukemogenesis. To explore the specific relationship between NPMc+ and FLT3/ITD in vivo, we crossed Flt3/ITD knock-in mice with transgenic NPMc+...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Duplication

Share to Leukemia, Myeloid, Acute

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Source

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Identifiers

PMID: 24184354
DOI: 10.1016/j.exphem.2013.10.005
PMCID: PMC3932758

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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