Article
Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia.
Blood - 15 Oct 2005
Suzuki Tatsuya, Kiyoi Hitoshi, Ozeki Kazutaka, Tomita Akihiro, Yamaji Satomi, Suzuki Ritsuro, Kodera Yoshihisa, Miyawaki Shuichi, Asou Norio, Kuriyama Kazutaka, Yagasaki Fumiharu, Shimazaki Chihiro, Akiyama Hideki, Nishimura Miki, Motoji Toshiko, Shinagawa Katsuji, Takeshita Akihiro, Ueda Ryuzo, Kinoshita Tomohiro, Emi Nobuhiko, Naoe Tomoki
Abstract excerpt
Recently, somatic mutations of the nucleophosmin gene (NPM1), which alter the subcellular localization of the product, have been reported in acute myeloid leukemia (AML). We analyzed the clinical significance of NPM1 mutations in comparison with cytogenetics, FLT3, NRAS, and TP53 mutations, and a partial tandem duplication of the MLL gene (MLL-TD) in 257 patients with AML. We found NPM1 mutations, including 4...
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