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Article

When the good go bad: Mutant NPM1 in acute myeloid leukemia.

Blood reviews - 1 May 2018

Kunchala Preethi, Kuravi Sudhakiranmayi, Jensen Roy, McGuirk Joseph, Balusu Ramesh

Abstract excerpt

Nucleophosmin 1 (NPM1) is a nucleolar phosphoprotein that performs diverse biological functions including molecular chaperoning, ribosome biogenesis, DNA repair, and genome stability. Acute myeloid leukemia (AML) is a heterogeneous disease, more than half of the AML cases exhibit normal karyotype (NK). Approximately 50-60 percent of patients with NK-AML carry NPM1 mutations which are characterized by cytoplasmic...

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Topics

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Share to Protein Processing, Post-Translational
Share to Antineoplastic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gain of Function Mutation

Share to Leukemia, Myeloid, Acute

Share to Molecular Targeted Therapy

Share to Nuclear Proteins

Share to Nucleophosmin

Share to Translocation, Genetic

Source

Identifiers

PMID: 29157973
DOI: 10.1016/j.blre.2017.11.001

Genes

NPM1
HAUS1
TYK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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