Article
Distinctive expression of myelomonocytic markers and down-regulation of CD34 in acute myelogenous leukaemia with FLT3 tandem duplication and nucleophosmin mutation.
European journal of haematology - 1 Jul 2007
Mori Yasuo, Yoshimoto Goichi, Kumano Takashi, Miyamoto Toshihiro, Iino Tadafumi, Takenaka Katsuto, Iwasaki Hiromi, Harada Naoki, Kinukawa Naoko, Nagafuji Koji, Teshima Takanori, Shimoda Kazuya, Akashi Koichi, Harada Mine
Abstract excerpt
OBJECTIVE: Patients with acute myelogenous leukaemia (AML) show co-existing frequently internal tandem duplications of FLT3 (FLT3-ITD) and mutations of nucleophosmin (NPM1-Mt). We investigated the biological and clinical significance of FLT3-ITD and/or NPM1-Mt in this context. METHODS: We analysed 89 AML patients according to whether NPM1 and FLT3-ITD were single mutants, double mutants, or wild type for both....
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