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Article

A knock-in Npm1 mutation in mice results in myeloproliferation and implies a perturbation in hematopoietic microenvironment.

PloS one - 1 Jan 2012

Chou Shiu-Huey, Ko Bor-Sheng, Chiou Ji-Shain, Hsu Yueh-Chwen, Tsai Mong-Hsun, Chiu Yu-Chiao, Yu I-Shing, Lin Shu-Wha, Hou Hsin-An, Kuo Yi-Yi, Lin Hsiu-Mei, Wu Ming-Fang, Chou Wen-Chien, Tien Hwei-Fang

Abstract excerpt

Somatic Nucleophosmin (NPM1) mutation frequently occurs in acute myeloid leukemia (AML), but its role in leukemogenesis remains unclear. This study reports the first "conventional" knock-in mouse model of Npm1 mutation, which was achieved by inserting TCTG after nucleotide c.857 (c.854_857dupTCTG) to mimic human mutation without any "humanized" sequence. The resultant mutant peptide differed slightly different...

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Share to Chemokine CXCL12
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Myeloid, Acute

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Source

Open in PubMed Open full text

Identifiers

PMID: 23226219
DOI: 10.1371/journal.pone.0049769
PMCID: PMC3511491

Genes

CXCL12
CXCR4
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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