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Article

MAGE cancer-testis antigens protect the mammalian germline under environmental stress

3 May 2019

Abstract excerpt

genes disrupts spermatogonial stem cell maintenance and impairs repopulation efficiency in vivo. Exposure of Mage-a knockout mice to genotoxic stress or long-term starvation that mimics famine in nature causes defects in spermatogenesis, decreased testis weights, diminished sperm production, and reduced fertility. Last, human MAGE-As are activated in many cancers where they promote fuel switching and growth of...

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PMID: 31149633
DOI: 10.1126/sciadv.aav4832

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