Non-Genetic Mechanisms in Cancer Evolution: Senescence, Unicellularization, and Cycles of Stemness Recovery

Abstract excerpt

All germlines - including those of humans, protists, cancer, and metazoans - are capable of proliferating through asymmetric cell division, giving rise to committed stem cells. Their common evolutionarily roots trace back to the hypoxic germline of the last common ancestor of amoebozoans, metazoans, and fungi - referred to as the Ur-germline. Consequently, all modern germlines that produce stem cells - including t...

Topics

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• Cellular Senescence
• DNA Damage
• DNA Repair
• Genomic Instability
• Mutation
• Neoplasms
• Stem Cells
• Telomeres, Telomerase, and Senescence

Identifiers and source

Literature Corpus work

82446895-eeed-5ac5-bc98-f835c644fc81

DOI

10.20944/preprints202501.0799.v2