Article

The mutational landscape of human somatic and germline cells

2020-11-26

Abstract excerpt

During the course of a lifetime normal human cells accumulate mutations. Here, using multiple samples from the same individuals we compared the mutational landscape in 29 anatomical structures from soma and the germline. Two ubiquitous mutational signatures, SBS1 and SBS5/40, accounted for the majority of acquired mutations in most cell types but their absolute and relative contributions varied substantially. SBS1...

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Literature Corpus work: f082eac4-51f6-5f41-9f08-b326da59a1cb
DOI: 10.1101/2020.11.25.398172

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