Article

Cancer Genomics: Restorative Senescence, Transition to Unicellularity, DDR Circuits, and the Status Quo Ante

2025-01-10

Abstract excerpt

All non-gametogenic germlines, including those of humans, protists, and cancer, are capable of proliferation through asymmetric cell division (ACD) and stem cell differentiation, and can be classified as NG germlines or CSC-germlines. These cells are evolutionary descendants of the hypoxic Urgermline that evolved from the common ancestor of amoebozoans, metazoans, and fungi, and follow its physiological and molecu...

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Literature Corpus work: 34e3c612-2e99-5971-8f57-7c8fccedfeb8
DOI: 10.20944/preprints202501.0799.v1

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