Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell analysis of human testis aging and correlation with elevated body mass index

1 May 2022

Abstract excerpt

Aging men display reduced reproductive health; however, testis aging is poorly understood at the molecular and genomic levels. Here, we utilized single-cell RNA-seq to profile over 44,000 cells from both young and older men and examined age-related changes in germline development and in the testicular somatic cells. Age-related changes in spermatogonial stem cells appeared modest, whereas age-related...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Birth, Development, and Health
Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35504286
DOI: 10.1016/j.devcel.2022.04.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell analysis of human testis aging and correlation with elevated body mass indexPMID 35504286Read ↗

Single-Cell Analysis of Human Testis Aging, and Impact of Elevated Body Mass IndexSemantic proximity Read ↗

Multi-Omics Perspectives on Testicular Aging: Unraveling Germline Dysregulation, Niche Dysfunction, and Epigenetic RemodelingSemantic proximity Read ↗

A single-nucleus transcriptomic atlas of primate testicular aging reveals exhaustion of the spermatogonial stem cell reservoir and loss of Sertoli cell homeostasisSemantic proximity Read ↗

Transcriptomic landscape and potential therapeutic targets for human testicular aging revealed by single-cell RNA sequencingSemantic proximity Read ↗

A single-cell transcriptomic landscape of mouse testicular agingSemantic proximity Read ↗

Single-cell RNA sequencing reveals transcriptomic landscape and potential targets for human testicular ageingSemantic proximity Read ↗

Single-cell transcriptomics identifies senescence-associated secretory phenotype (SASP) features of testicular aging in human.Semantic proximity Read ↗

Testicular aging, male fertility and beyondSemantic proximity Read ↗

Transcriptomic and epigenomic profiling of young and aged spermatogonial stem cells reveals molecular targets regulating differentiationSemantic proximity Read ↗

Application of single-cell RNA sequencing on human testicular samples: a comprehensive reviewSemantic proximity Read ↗

The Dynamic Transcriptional Cell Atlas of Testis Development during Human PubertySemantic proximity Read ↗

A single-cell atlas of the aging murine ovarySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.