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The dynamic epigenetic program in male germ cells: Its role in spermatogenesis, testis cancer, and its response to the environment

24 Mar 2009

Abstract excerpt

Spermatogenesis is a truly remarkable process that requires exquisite control and synchronization of germ cell development. It is prone to frequent error, as paternal infertility contributes to 30-50% of all infertility cases; yet, in many cases, the mechanisms underlying its causes are unknown. Strikingly, aberrant epigenetic profiles, in the form of anomalous DNA and histone modifications, are characteristic of...

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PMID: 19319879
DOI: 10.1002/jemt.20715

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