Article

Single-Cell Analysis of Human Testis Aging, and Impact of Elevated Body Mass Index

2021-10-20

Abstract excerpt

<h4>SUMMARY</h4> Aging human males display reduced reproductive health, however testis aging is poorly understood at the molecular and genomic level. Here, we utilized single-cell RNA-seq to profile over 44,000 cells from both young and older men (>60 years old) – and examined age-related changes in germline development and in the somatic niche. Interestingly, age-related changes in spermatogonial stem cells appe...

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Literature Corpus work: 27323896-c755-5ef6-8ce6-8dbff1299d60
DOI: 10.1101/2021.10.19.464550

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