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Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks

1 May 2019

Abstract excerpt

In chronic lymphocytic leukemia (CLL), a diverse set of genetic mutations is embedded in a deregulated epigenetic landscape that drives cancerogenesis. To elucidate the role of aberrant chromatin features, we mapped DNA methylation, seven histone modifications, nucleosome positions, chromatin accessibility, binding of EBF1 and CTCF, as well as the transcriptome of B cells from CLL patients and healthy donors. A...

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PMID: 31118277
DOI: 10.15252/msb.20188339

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