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Article

Chronic lymphocytic leukemia (CLL) risk is mediated by multiple enhancer variants within CLL risk loci.

Human molecular genetics - 29 Sept 2020

Yan Huihuang, Tian Shulan, Kleinstern Geffen, Wang Zhiquan, Lee Jeong-Heon, Boddicker Nicholas J, Cerhan James R, Kay Neil E, Braggio Esteban, Slager Susan L

Abstract excerpt

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in Western countries. It has a strong genetic basis, showing a ~ 8-fold increased risk of CLL in first-degree relatives. Genome-wide association studies (GWAS) have identified 41 risk variants across 41 loci. However, for a majority of the loci, the functional variants and the mechanisms underlying their causal roles remain undefined. Here, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 32744316
DOI: 10.1093/hmg/ddaa165
PMCID: PMC7530532

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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