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Genome-wide DNA methylation analysis reveals novel epigenetic changes in chronic lymphocytic leukemia

1 Jun 2012

Abstract excerpt

We conducted a genome-wide DNA methylation analysis in CD19 (+) B-cells from chronic lymphocytic leukemia (CLL) patients and normal control samples using reduced representation bisulfite sequencing (RRBS). The methylation status of 1.8-2.3 million CpGs in the CLL genome was determined; about 45% of these CpGs were located in more than 23,000 CpG islands (CGIs). While global CpG methylation was similar between CLL...

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PMID: 22534504
DOI: 10.4161/epi.20237

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