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Uncovering the DNA methylome in chronic lymphocytic leukemia

15 Jan 2013

Abstract excerpt

Over the past two decades, aberrant DNA methylation has emerged as a key player in the pathogenesis of chronic lymphocytic leukemia (CLL), and knowledge regarding its biological and clinical consequences in this disease has evolved rapidly. Since the initial studies relating DNA hypomethylation to genomic instability in CLL, a plethora of reports have followed showing the impact of DNA hypermethylation in...

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PMID: 23321535
DOI: 10.4161/epi.23439

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