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Article

Epigenetic and genetic alterations and their influence on gene regulation in chronic lymphocytic leukemia.

BMC genomics - 16 Mar 2017

Huang Di, Ovcharenko Ivan

Abstract excerpt

BACKGROUND: To understand the changes of gene regulation in carcinogenesis, we explored signals of DNA methylation - a stable epigenetic mark of gene regulatory elements - and designed a computational model to profile loss and gain of regulatory elements (REs) during carcinogenesis. We also utilized sequencing data to analyze the allele frequency of single nucleotide polymorphisms (SNPs) and detected the...

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Share to CpG Islands
Share to DNA Methylation
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

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Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Identifiers

PMID: 28302063
DOI: 10.1186/s12864-017-3617-6
PMCID: PMC5353786

Genes

PAX5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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